Catalepsy vs cataplexy1/5/2023 ![]() Commonly Xyrem is prescribed as its activity reduces EDS and improves the quality of night time sleep and may be involved in assisting the repair on the brain during sleep when it is least active. Other drugs which are less effective stimulants but have lower abuse potentials include atomoxetine which inhibits the reuptake of noradrenalin allowing it to persist allowing its effects such as increasing heart rate, promotion of glucose release from the muscles and increasing blood flow to the brain to persist.Ĭataplexy on the other hand needs its own special attention. For this reason both –dafinals are monitored for potential abuse and addiction. Exactly how these drugs work is not known but what we do know is they work differently to amphetamines and some attributes are shared, such as the effects of the drugs on dopamine levels in the brain. ![]() Amphetamine based drugs were favoured but new drugs like Modafinil and Armodafinil are now used instead. Initially central nervous system (CNS) stimulants are given. Treating such an unusual disease necessarily takes an individual by individual response but certain guidelines are followed. What is orexin? Orexin is a fundamental controller of both appetite and sleep-patterning suggesting that some forms of narcolepsy are in fact an autoimmune disease! Some, not all, narcoleptics show a number of important variations in their HLA’s that increase their ability to target orexin-producing neurons in the brain. I won't go into it here but the HLA is related to antibodies, which the body uses to identify things that shouldn’t be in the body and target them for removal. Despite the neurological trigger it is predicted that both conditions share a level of genetic involvement as well as both conditions have been shown to run in families.Īn interesting discovery in narcolepsy research is the involvement of a region of DNA on chromosome 6 involved in the production of human leukocyte antigen ( HLA, a.k.a Major Histocompatability Complex or MHC in mice). Credit: me.īoth narcolepsy and cataplexy can appear at the same time as both have similar triggers, most notably strong emotional reactions, which can set them off together. I don't think my dogs are narcoleptic, just lazy. The cataplexy and sleep paralysis reflect the encroachment of REM atonia into wakefulness resulting in muscle paralysis when it is not desired. REM sleep is when dreaming occurs which explains the hypnagogic hallucination as there is no non-REM ( NREM) sleep to buffer dreaming from wakefulness (hypnagogic means sleep leading and refers to the transition sleep to awake and vice versa). Essentially this, alongside all the other symptoms suggests the brain does not follow the normal pattern of sleep. Most people take approximately 90 min to achieve this level of sleep and this is a really significant part of the problem. ![]() For sufferers this condition is understandably terrifying.Īnother of the defining characteristics of narcolepsy is that its sufferers seem to have the ability to enter deep rapid eye movement ( REM) sleep in as little as 10 min. Some only suffer from weakness in facial muscles that fades quickly but in severe cases the weakness can be felt in all skeletal muscles at the same time causing the sufferer to drop (if you'll mind the use of the word) into a paralysed state while remaining entirely conscious of their surroundings and what is happening to them. Cataplexy, like narcolepsy, has varying degrees of severity. Narcolepsy is characterised by four basic symptoms known as the ‘tetrad of narcolepsy’, cataplexy, sleep paralysis, hypnagogic hallucinations (hallucinations associated with the transition between asleep and awake) and excessive daytime sleepiness (EDS).Ĭataplexy is simply one of the characteristics of narcolepsy and refers to a sudden onset muscle weakness, which can be experienced alongside or independently from narcolepsy. So what’s the difference and what’s the deal with narcolepsy? Credit: įurthermore narcolepsy is often confused with cataplexy, a related yet very distinct condition. ![]()
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Remember the Claw Machines to win the cuddly toys? Well now you can play that by guiding the claw or sneaking a tentacle in to grab a toy the unconventional way. #Octodad dadliest catch final fullOne of the best places Octodad ends up in whilst visiting the Aquatic Center is a jungle themed arcade room full of classic arcade games that we’ll have all probably seen or played in our lifetimes. The shop can get a bit messy though, as do basically every other environment you travel through I spared a thought for the clean-up crews as I was clambering around. ![]() #Octodad dadliest catch final how toHowever, when the body you control feels similar to that of a puppet on a string, just planning how to navigate the shopping aisles without arousing suspicion and how silly it all looks makes it all the more enjoyable. Taking on a variety of ordinary dad-like duties, I totally expected to get bored when asked to mow the lawn or pick up the kids’ favourite cereal from the local store. It takes a hell of a long while to get used to controlling Octodad and even now I still quite often turn into Bambi on ice. Without the trigger pressed, each analog stick works as a movement for his arm with one stick moving it up and down whilst the other moves it backwards and forwards. Given the control scheme this is a tricky task Octodad doesn’t move like a human nor do you control him like one, instead you can move one leg with each trigger and an analog stick. The story itself, although fun, plays second fiddle to the rather unique gameplay.ĭespite being a cartoony adventure game, there’s a substantial amount of stealth orientated play involved if you want to succeed in not being found out, without resorting to lowering the difficulty to Easy. ![]() No one can tell he’s not an ordinary dad, although it’s quite blinking obvious, and he hopes to keep it that way especially with the crazed Chef Fujimoto chomping at the bit to expose him to the world. Eventually, when stealth sections are mixed in, things do become more complicated than picking things up and putting them down, but the gameplay doesn't really evolve past the humor inherent in the core concept of the game.Octodad is just trying to get by in his mundane family life, doing the normal things a dad to Stacy and Tommy and husband to Scarlet would do attempting to stay out of trouble and avoiding unnecessary attention. The more you play the more natural it feels, but it never gets to the point where the relatively simple objective of "Chop firewood" is anything less than a Herculean task. Moving your arms is just as difficult, and picking things up? Crazy difficult at first. Instead, you need to swing your tentacles around one at a time like you're trying to run without feeling in your legs. That, or it could have been longer-either way, you won't be happy with how much is there, for how much it costs. 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I feel no embarrassment in admitting that Senua’s story of self-doubt and her struggles with mental illness have damn-near reduced me to tears on more than one occasion. The story begins with her believing that she’s deserving of the curse that was set upon her, and the tale is of her journey in becoming a mighty warrior of body and mind.Ī key focus of the story is Senua’s psychosis and, coming from someone that has suffered from forms of temporary psychosis, the developers at Ninja Theory handled the story with the utmost dignity and respect. The developer also worked with neuroscientists, mental health charities, and those diagnosed with psychosis. Senua’s story takes the centre stage in Hellblade. Credit: Ninja Theory Senua – Hellblade: senua’s sacrifice ![]() Fairway solitaire blast game1/4/2023 ![]()
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